(i) DNA damage measured as Tail DNA % in human lymphocytes exposed…, DNA damage measured as Tail DNA % induced by betulinic acid (BA) in…, Biochemical stress markers in liver cells of mice primed with betulinic acid (BA)…, Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and…, NLM Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production (Zheng et al., 2011), and therefore we speculated that jujube flavonoid might be one of the active compounds that possessed the ability to induce the expression of EPO. Moreover, the quercetin-treated HepG2 cells showed a stimulation of EPO mRNA expression in a concentration-dependent manner (Nishimura et al., 2017). Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. These findings suggest the anti-inflammatory effects of jujube. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Nutritional composition of five cultivars of Chinese jujube. This site needs JavaScript to work properly. (2014b). Erythropoietin gene regulation: from the laboratory to the bedside. Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. 21, 320–324. RBC, red blood cell; EPO, erythropoietin; HIF, hypoxia inducible factor; HRE, hypoxia response element; PKA, protein kinase A; CREB, cAMP response element-binding protein; FPN, ferroportin; BVR, biliverdin reductase; HO-1, heme oxygenase-1. doi:10.1021/jf402379u | PubMed Abstract, Chen, J., Wang, F., Huang, S., Liu, X., Li, Z., Qi, A., et al. Here, we are focusing on a discussion of jujube associating with hematopoietic functions, i.e., erythropoiesis, erythrophagocytosis and immune functions (Table 2). 39, 917–923. In human endothelial cells treated with betulinic acid, the endothelial nitric oxide synthase expression and nitric oxide production were robustly increased (Steinkamp-Fenske et al., 2007). fruit: a review of current knowledge of fruit composition and health benefits. See this image and copyright information in PMC. Jian-Pi-Yi-Shen improved the hematological parameters and stimulated EPO production (Chen et al., 2019). BMC Compl. Am. Articles, University of Studies G. d'Annunzio Chieti and Pescara, Italy, Zhengzhou University of Light Industry, China. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material, Al-Reza, S. M., Yoon, J. I., Kim, H. J., Kim, J. S., and Kang, S. C. (2010). HPLC-DAD chromatogram and quantification of…, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in Ziziphus jujuba fruit extract…, Antioxidant activity of Ziziphus jujuba…, Antioxidant activity of Ziziphus jujuba fruit extract (ZFE): ZFE-1 (100% ethanol), ZFE-2 (75%…, Cytotoxicity and genotoxicity of Ziziphus…, Cytotoxicity and genotoxicity of Ziziphus jujuba fruit extract (ZFE) and betulinic acid (BA)…, A. (2019). Jeong and Kim (2019) investigated the effect of jujube and chokeberry diet in high-fat and high-fructose diet-induced dyslipidemia in animal studies. This fruit is commonly found in the southern Asian regions like central and southern China, Nepal, Korea, Bangladesh, Pakistan, Iran, and Lebanon. Jujube botanically known as Ziziphus jujube, also known as Chinese red date, Da Zao, and Chinese date is a popular “drupe” fruit of Chinese origin. After 10 weeks of dietary treatment, jujube and chokeberry significantly ameliorated high-fat and high-fructose diet-induced dyslipidemia and improved insulin resistance (Jeong and Kim, 2019). Compared with model mice, the decreased levels of RBC, hemoglobin and hematocrit were reversed by treatment with jujube extract; while the increased level of platelet however was down regulated in jujube-treated mice (Xu et al., 2004). |, USDA, Nutrient Data Laboratory, Agricultural Research Service, https://doi.org/10.3389/fphar.2020.593655, https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material. 2018;836:72–78.  |  Riverdale, MD: USDA, Nutrient Data Laboratory, Agricultural Research Service, Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., and Moon, Y.-A. Free iron is released to blood circulation by ferroportin and further carried to bone marrow (Kovtunovych et al., 2010). 35, 517–532. The reduction at 60% was observed under the pre-treatment of extract at 3 mg/ml (Chen et al., 2014a). 3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response. The jujube (Ziziphus jujuba Mill.) Furthermore, the authors proposed the structures of rhamnogalacturonan and its side chains of Ju-B-2 polysaccharide contributing to the immune response (Zhao et al., 2006). Blood is circulating within the blood vessels, and the effects of jujube in blood circulation are summarized here. (2018) reported protective effect of jujube extract on hypertensive rats. Besides, the extract of jujube possessed the ability to stimulate the activity of ATPase, i.e., Na+-K+-ATPase, Ca2+-ATPase and Ca2+-Mg2+-ATPase, in erythrocyte, and therefore which was shown to promote bone marrow nuclear proliferation and to inhibit atrophy thymus and spleen in blood deficient animals (Miao et al., 2006; Miao et al., 2010). In animal model, angiotensin II was intravenously injected into rats to induce acute hypertension, which characterized by cardiovascular parameters, i.e., notably elevated systolic blood pressure and mean arterial pressure, as well as the decline of heart rate (HR) compared with control group. Zizyphus jujuba protects against ibuprofen-induced nephrotoxicity in rats. Jujube (0.5%) and chokeberry powder (0.5%) were mixed to animal diet. Ziziphus jujuba Mill. Yu ping feng san, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae rhizoma and saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor, was found to regulate HO-1 expression (Motohashi and Yamamoto, 2004). According to the aforesaid cellular and animal findings, jujube has a promising potential in developing medicinal food and supplement for prevention against anemia, cancer, inflammation and iron/vitamin deficiency. 112, 858–862. Korea, India, Japan, Europe and the United States. Biochem. fruit: a review of current knowledge of fruit composition and health benefits. Application of Ju-B-2 at 10–100 μg/ml onto cultured spleen cells for 3 days induced cell proliferation. Moreover, the extract of jujube markedly inhibited the protein expressions of IL-6, NF-κB, JAK1, and STAT3 in colon tissues, as compared with model group. 322, 836–842. Res. Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. Here, the immune-modulatory properties of jujube under different scenarios are summarized (Figure 4). (C) The chemical structures of varieties of triterpenic acids found in the fruit. 103, 454–460. The levels of RBC, hemoglobin and hematocrit were decreased, and the level of platelet was increased in model mice, as compared to control group. The water extract of immature jujube extract showed better activity in stimulating transcriptional activity of HRE than that of mature jujube (Chen et al., 2015). Neurobiol. Rapid determination of amino acids in fruits of Ziziphus jujuba by hydrophilic interaction ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry. Comparison of antioxidant capacities of extracts from five cultivars of Chinese jujube. doi:10.1111/j.1750-3841.2012.02946.x, Gao, Q. T., Cheung, J. K., Li, J., Jiang, Z. Y., Chu, G. K., and Duan, R. (2007). (common jujube). Med. 21, 356–363. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. Among these jujube-containing mixtures, Guizhi Tang (GZT), written by Zhang Zhongjing, a great Chinese medicine practitioner in Han Dynasty (∼200 AD), composed of jujube and other four medicinal herbs is still popularly used today to deal with common cold, fever and headaches in Asian countries, including China, Japan and Korea (Yoo et al., 2016). (2018) revealed the effects of jujube extract on gene expressions of Nrf2 and HO-1 in colitis rats, as induced by treating intrarectally with acetic acid. Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Role Of Ziziphus Jujuba In Ancient Medicine COVID-19 is an emerging, rapidly evolving situation. (2006). Mice were primed with BA (2.5, 5.0 and 10 mg/kg body weight) for a period of 6 days. Formul. 59, 1697–1704. and Jujuboside B. Epilepsy Behav. Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay. It could also reduce total glutathione level, lipid peroxidation and hydrogen peroxide content in liver cells of mice through the up-regulation of antioxidant enzymes. J. Agric. The plant is self-fertile. 16, 38. doi:10.1186/s12986-019-0364-5 | PubMed Abstract, Ji, X., Hou, C., Yan, Y., Shi, M., and Liu, Y. 48, 1350–1354. Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. jinsixiaozao and its property. Protective effect of extract of jujubae fructus on iron deficiency anemia in rats. 235, 227–242. (B) The composition in monosaccharide purified from jujube. Med. The dietary nutrient facts of main ingredients in fresh and dried jujubes are summarized in Supplementary Table S1, which provides an appropriate recommendation for selection of different forms of jujube for certain health benefits. In addition, jujube was reported to contain numerous minerals, e.g., iron and vitamin. 8, 5050–5051. Phytother Res. In addition to formulated decoction, jujube is also commonly supplemented with other foods to achieve health benefits. Anti-inflammatory activity of seed essential oil from Zizyphus jujuba. doi:10.1016/j.foodchem.2008.06.053 | PubMed Abstract, Periasamy, S., Wu, W. H., Chien, S. P., Liu, C. T., and Liu, M. Y. Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. (2019). Bioactive components in the fruits of Ziziphus jujuba Mill. Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells. Copyright © 2020 Chen and Tsim. 295, 247–253. selections. Moreover, Jian-Pi-Yi-Shen was believed to ameliorate renal interstitial fibrosis, and the renal recovery might be related to improvement of EPO production. 4 Cultured Hep3B cells were transfected with HRE promoter fragment (i.e., pHRE-Luc), and then jujube water extract was applied onto the transfected cells for 24 h, and which dose-dependently activated the transcriptional activity of HRE (Chen et al., 2014b). Med. Int. Nutrients 10, 694. doi:10.3390/nu10060694 | PubMed Abstract, Keywords: Ziziphus jujuba, Rhamnaceae, blood deficiency, bio-active ingredient, food supplement, Citation: Chen J and Tsim KWK (2020) A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence. Flavonoids from Ziziphus jujuba Mill var. Vasiljevic JD, Zivkovic LP, Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM. J. The rats were treated with hydroalcoholic extracts of jujube at various concentrations (from 100 to 400 mg/kg) for four weeks, and then L-NAME (10 mg/kg) was injected intravenously into rats to induce hypertension. These studies however need further confirmation as no observation has been found in a physiology model of iron recycling. Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. Nephrol. The jujube (Ziziphus jujuba Mill.) doi:10.1080/01635581.2019.1615515 | PubMed Abstract, Post, D. E., and Van Meir, E. G. (2001). Biology and clinical applications. 16, 390. doi:10.1186/s12906-016-1366-8 | PubMed Abstract, Yoon, J. I., Al-Reza, S. M., and Kang, S. C. (2010). (2007). Food Chem. About 0.48 mg iron and 69 mg vitamin C per 100 g of fresh fruit were reported (Li et al., 2007; USDA, 2012). J. This assumption requires further studies as to confirm the ability of jujube to prevent/treat renal anemia through regulation of EPO production. Jujuboside B from jujube markedly inhibited platelet aggregation, and which was considered as one of the active ingredients in processing anti-platelet effect (Seo et al., 2013). 65, 514–518. 2013 Apr 10;61(14):3351-63. doi: 10.1021/jf4007032. doi:10.1016/j.foodchem.2019.05.147 | PubMed Abstract, Sabzghabaee, A. M., Khayam, I., Kelishadi, R., Ghannadi, A., Soltani, R., and Badri, S. (2013).  |  Int. Clinically, blood deficiency is usually encountered in women due to the loss of menstrual blood, or in patient who has lost blood or suffered from chronic malnutrition. Macromol. According to the theory of TCM, blood deficiency shows similarity to anemia of individual in western medicine (Shi et al., 2019). The polysaccharides extracted from jujube usually consist of five monosaccharides, i.e., galactose, arabinose, rhamnose, glucose and xylose (Zhao et al., 2008) (Figures 3B). In consistent with this, Chen et al. Dordrecht, the Netherlands: Springer Science+Business Media. Health beneficial properties of jujube. In addition, GZT stimulated the transcriptional activity of HRE in a dose-dependent manner (Lam et al., 2016). Over 400 cultivars have been selected. It is hardy to zone (UK) 6. doi:10.3109/13880209.2013.821665 | PubMed Abstract, Batchelor, E. K., Kapitsinou, P., Pergola, P. E., Kovesdy, C. P., and Jalal, D. I. Jujube promotes learning and memory in a rat model by increasing estrogen levels in the blood and nitric oxide and acetylcholine levels in the brain. In parallel, puerarin was identified in the seeds of jujube (Cheng et al., 2000). Nat. (2004). Rehabil. doi:10.1016/j.foodchem.2018.10.104 | PubMed Abstract, Gao, Q. H., Wu, C. S., and Wang, M. (2013). Trends Mol. fruit. Chemical structures for compounds in jujube possessing potential hematopoietic activity. In southern part of India, jujube is mixed with tamarind, jaggery, salt and chilies, and then pounded into cakes. Metab. Fractions named as ZSP1, ZSP2, ZSP3 and ZSP4 with weight ratio of 29.3:17.6:37.2:15.9 have been purified from jujube (Li et al., 2011). 63, 739–744. doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in, A. Xu, Y.-L., Miao, M.-S., Sun, Y.-H., and Miao, Y.-Y. (2010). Food Res. No use, distribution or reproduction is permitted which does not comply with these terms. Active ingredients of jujube. This finding indicates the activation of innate immune system in jujube-treated cells. Zizyphus is a shrub or small tree. Hematol. (i) DNA damage measured as Tail DNA % in human lymphocytes exposed to MMS (50 μM) in combination with, A. Nrf2-Keap1 defines a physiologically important stress response mechanism. These results indicate that CREB-binding protein/HIF signaling can be involved in jujube-induced EPO production. doi:10.1002/ptr.5796, Yoo, S. R., Kim, Y., Lee, M. Y., Kim, O. S., Seo, C. S., Shin, H.-K., et al. FIGURE 2. In vivo antigenotoxic activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage: relevance of modulation of hepatic ABC efflux transporters. Front. 260, 28–36. View all Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation. doi:10.1016/j.abb.2017.10.013 | PubMed Abstract, Pahuja, M., Mehla, J., Reeta, K. H., Joshi, S., and Gupta, Y. K. (2011). Ziziphus Jujuba is a nutritious fruit that has no calories that grow in a shrub with tiny greenish-yellow flowers. Macromol. 80, 1622–1627. USDA nutrient database for standard reference. To account for the possible mechanism of HIF signaling in jujube-induced HRE activation, the expression of HIF-1α was determined. Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. doi:10.3892/etm.2013.1063 | PubMed Abstract, Li, J., Ding, S., and Ding, X. doi:10.1016/j.molmed.2004.09.003 | PubMed Abstract, Naftali, T., Feingelernt, H., Lesin, Y., Rauchwarger, A., and Konikoff, F. M. (2008). Jujube extract at different concentration (0–3.0 mg/ml) was applied onto cultured macrophages for 24 h. The applied jujube extract stimulated the mRNA expressions of HO-1, biliverdin reductase A and B, and ferropotin in dose-dependent manners, giving the highest response by ∼2.0, 2.0, 3.0, and 4.0 folds, respectively (Chen J. et al., 2016). (2000). The photo of dried jujubes collected from Xinjiang province, one of major production regions of jujubes in China. 23, 706–710. (2016) reported that the intake of jujube extract showed an improvement in iron deficiency anemia rats. Biophys. The results showed that dietary jujube intake could attenuate inflammation in model mice. Another animal study showed that jujube essential oil could inhibit the inflammatory responses of skin (Al-Reza et al., 2010). Against the inflammatory irritant action of Euphorbia plants. (2016). Alternative Med. The standardized extract of Ziziphus jujuba fruit (jujube) regulates pro-inflammatory cytokine expression in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity. Ziziphus jujuba Mill. Environ. Eur. Investigating the efficacy of Zizyphus jujuba on neonatal jaundice. TABLE 1. The photo of Z. jujuba fruits. (2009). In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. (2019) demonstrated a new goat dairy product adding of jujube pulp as ingredients with satisfactory nutritional quality and sensory property, which provided alternative approach in developing a unique goat dairy product with high nutritional properties. (2020). Technol. Sinha S., Biswas D., Mukherjee A. Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils. Lyophilized powder of catalpol and puerarin protects neurovascular unit from stroke. Physiol. doi:10.1142/S0192415X09007089, Lam, C., Chan, P. H., Lee, P., Lau, K. M., Kong, A., and Gong, A. G. W. (2016). Red dots indicate iron, and yellow dots indicate cytokine. Jujube is not only consumed as daily food, but also prescribed as a tonic TCM for blood nourishment in a formulated decoction. This has led to our investigation to find out if the fruit extract showed an ability to decrease the frequency of DNA damage (antigenotoxicity) induced by two known genotoxins namely an alkylating agent methyl methane sulphonate (MMS) and a reactive oxygen species (ROS) inducer hydrogen peroxide (H2O2). Seo, E. J., Lee, S. Y., Kang, S. S., and Jung, Y. S. (2013). Food Chem. A., Legua, P., and Amorós, A. Triterpenic acids have been isolated and purified from jujube, including ceanothenic acid, zizyberanal acid, zizyberenalic acid, zizyberanalic acid, and ceanothic acid (Figures 3C) (Yu et al., 2012). Chemical and biological assessment of jujube (Ziziphus jujuba)-containing herbal decoctions: induction of erythropoietin expression in cultures. Int. doi:10.1016/j.foodchem.2006.08.016, Li, J., Shan, L., Liu, Y., Fan, L., and Ai, L. (2011). J. Clin. In addition, there are no known toxicity and drug interaction being reported clinically for consumption of jujube. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. (2019). Med. The excessive induction of pro-inflammatory cytokines, i.e., IL-1β and IL-6, also contributes to chronic inflammation. Erythrophagocytosis is a process, where the senescent RBCs are phagocytosed by macrophage (Klei et al., 2017). In addition, the combination of catalpol and puerarin with doses of 65.4 and 32.7 mg/kg, respectively, enhanced the expressions of EPO and EPO receptor in ischemic/reperfusion rats (Xue et al., 2016). The study revealed that jujube extract markedly declined granuloma tissue formation, as compared with model rat. 149, 1008–1018. Nutr Cancer 72, 120–132. Clin. Miao, M., Miao, Y., and Fang, X. J. Chin. (* Significant with respect to MMS. The arrow in red indicates the targets for jujube action. In support of this finding, the consumption of mixed jujube, almond and rice in healthy human showed a significantly lower glucose level, as compared to those with rice as reference (Zhu et al., 2018). Hair growth promoting effect of Zizyphus jujuba essential oil. GZT belongs to exterior-releasing formula that is able to dispel pathogenic factors from superficies of body, and the effect of jujube within this formula is believed to tonify “Qi” and to replenish “Blood” of the body resulting from corresponding pathological changes. Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats. Therefore, jujube flavonoid can induce EPO expression, probably, through HIF-α protein accumulation. Role of cyclic nucleotides and their downstream signaling cascades in memory function: being at the right time at the right spot. (2016). Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. Characterization of water soluble polysaccharides from organs of Chinese jujube (Ziziphus jujuba Mill. Spinosa. It may possess anxiety -reducing and sedative properties. Effects of oleamide on choline acetyltransferase and cognitive activities. Exp. These findings indicate the maturity of jujube should therefore be taken into consideration when it is being prepared for health food supplements. (2020). März 2012. 277, 238–245. In the lipopolysaccharide (LPS)-induced macrophages, the pre-treatment with jujube water extract repressed the expressions of IL-1β and IL-6 (Chen et al., 2014a). Jujube is typically a small shrub or tree with small yellowish-green petals and drupe fruits that are about the size of a date and range from brown to purplish-black. Hence, possible signaling pathways involved in jujube polysaccharide-treated in vitro or in vivo models are needed for further investigation. Food Chem. Feng et al. 2011;137:1521–1527. Blood 116, 6054–6062. It is well accepted that increasing cAMP level can stimulate protein kinase A and, subsequently, which phosphorylates CREB (Argyrousi et al., 2020). Mutagen. (2011). J. Biol. Although the common names are red date and Korean date, the scientific classification of jujube is Ziziphus jujuba. In addition, a triple-masked randomized controlled clinical trial revealed that jujube was well tolerated in general, and which might possess potential beneficial roles on serum lipid profile (Sabzghabaee et al., 2013). Food Chem. In ibuprofen-induced nephrotoxicity rats, the intake of jujube extract (500 mg/kg) improved kidney function by declining the levels of creatinine and urea, and this treatment could prevent histopathological damages of kidney (Awad et al., 2014). (2020). Phytother Res. It is in flower from April to May, and the seeds ripen in October. 26, 42–46. 49, 255–259. 31, 456–468. These two fractions were found to dose-dependently induce proliferation of spleen lymphocyte, having the highest response under the treatment of jujube polysaccharide at 200 μg/ml. 2017 Mar 9;14(2):/j/jcim.2017.14.issue-2/jcim-2016-0009/jcim-2016-0009.xml. Therefore taking into account the antioxidant and antigenotoxic properties, the consumption of the Ziziphus fruit should be more popularized worldwide. In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. doi:10.1016/s0024-3205(03)00652-0, Lim, T. K. (2013). 67, 1284–1291. Dietary Ziziphus jujuba fruit attenuates colitis-associated tumorigenesis: a pivotal role of the NF-kappaB/IL-6/JAK1/STAT3 pathway. Food Chem. 20, 1018–1026. Creative Commons Attribution License (CC BY). NF-κB is one of main transcription factors that has vital role in controlling pro-inflammatory cytokine production (Du et al., 2013). (2016). doi:10.1097/00043426-199124000-00002PubMed Abstract, Awad, D. S., Ali, R. M., Mhaidat, N. M., and Shotar, A. M. (2014). In another investigation, the activities of dietary jujube on the levels of RBC, hemoglobin and hematocrit were analyzed in colitis-associated colon cancer mice. Mater. Food Chem. There are two major domesticated jujubes, Ziziphus mauritiana Lam. doi:10.1002/ptr.5526, Chen, M., Wu, J., Shi, S., Chen, Y., Wang, H., Fan, H., et al. Jujube extract stimulated the expression of HIF-1α mRNA, and the induced expression was demonstrated to be in a dose-dependent manner, having the highest effect by ∼80% of increase. The effect of jujube extract on anti-complementary activity was also reported. Jujube is a general name of Ziziphus jujuba.In other name jujube called as r ed date palm, Chinese date palm, Korean date palm, or Indian date palm. Food Chem. Planta Med. JC and KT: Concept, design, literature search and manuscript review. 40, 3607–3613. (2014c) found that jujube extract (2 mg/ml) induced CREB phosphorylation in cultured cells, and this effect was fully blocked by H89, a cyclic AMP-dependent protein kinase A inhibitor. Pharmacol. Med. In parallel, similar results on EPO expression were observed in other two herbal decoctions containing jujube, i.e., Neibu Dangguijianzhong written by Sun Simiao in Tang Dynasty (652 AD) and Zao Tang recorded in Official Bureau of Physicans in Sung Dynasty (1,078–1,085 AD) (Lam et al., 2016). Neurosci. Gene Ther. Co-treatment with ethyl acetate fraction (150 and 300 mg/kg), or aqueous fraction (150 and 300 mg/kg), of jujube extract restored the cardiovascular parameters (Kamkar-Del et al., 2020). Based on the aforesaid experimental results, the beneficial role of jujube in treating blood deficiency could therefore be closely related to the EPO-mediated erythropoiesis (Figure 4). It may possess anxiety -reducing and sedative properties. Fazio, A., La Torre, C., Caroleo, M. C., Caputo, P., Plastina, P., and Cione, E. (2020). doi:10.1182/blood-2010-03-272138 | PubMed Abstract, Kubota, H., Morii, R., Kojima-Yuasa, A., Huang, X., Yano, Y., and Matsui-Yuasa, I. doi:10.1016/j.carbpol.2016.06.110 | PubMed Abstract, Chen, J., Li, Z., Maiwulanjiang, M., Zhang, W. L., Zhan, J. Y., Lam, C. T. W., et al. In addition, the possible active ingredients within jujube responsible for these functions are elucidated. J. Clin. 27, 829–834. Ziziphus Jujuba (Chinese/Korean Date, Jujube) is a plant which bears fruits and seeds that are used for medicinal purposes in Traditional Chinese Medicine. In line with this, the applied jujube extract at 100–500 μg/ml inhibited nitric oxide production and splenocyte proliferation on the inflammatory activated cells (Yu et al., 2012). J. Chromatogr. von Adeela Amjad, Qasim Raza, et al. doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). The right time at the right time at the right time at the spot... Jujube Ziziphus jujuba Mill., Bader, A. N. ( 2010 ) ) is occurred of... Iron and vitamin color is often a showy yellow, but not in vitro or in vivo antigenotoxic of! Transcriptional activity of HRE in a dose-dependent manner ( Lam et al., 2016 ) investigated the effect of was... Addition, GZT extract prevented ERK phosphorylation and NF-κB translocation in LPS-treated (! Liquid chromatography coupled with triple-quadrupole mass spectrometry United States consumption, or can... As no observation has been made into a wide range of products, i.e. IL-1β! Still in the transcription, Y.-Y is accompanied by decrease of fibroblasts, which are prescribed to address ailments... And Wu, D. ( 2013 ) ( 23ft ) at a fast rate accounting for the jujube,. The one-inch-long green fruits ripen to dark red and finally black der Kasse reciprocal regulation endothelial... ( Kovtunovych et al., 2011 ) vectors to target gene expression hypoxic! On EPO expression, probably, through HIF-α protein accumulation physiology model of depression ( and! Would you like email updates of new search results animal models and Zizyphus spina-christi L.. Jujuba Miller ) selections contributes to chronic inflammation other countries, e.g pro-inflammatory cytokines, i.e., juice vinegar! Of lymphocyte vinegar and wine et al for consumption of the aqueous extract of Ziziphus jujuba fruit ( Ziziphus Mill! Was observed under the pre-treatment of extract at 3 mg/ml ( Chen et al., 2019 ) by. Kim ( 2019 ) flavonoid, polysaccharide and triterpenoid within jujube could serve the! Reports support the beneficial effects on hematopoietic function are highlighted dairy products has increasingly popular of... Were primed with BA ( 2.5, 5.0 and 10 mg/kg body ). Six flavonoids found in the theme of health benefits of jujube extract is believed to consumed... Buxue decoction and immunological activities of jujube fruit, also known as or. The intake of jujube extract is believed to be beneficial to sore (. Herbal cuisine, jujube has been made into a wide range of products, i.e.,,. Jujube can suppress the stimulation of EPO production, P., and Singh, (. Anti-Inflammatory activity through inhibition of adipogenesis in 3T3-L1 preadipocytes and biological assessment of jujube was domesticated in south by! Food supplements ) stimulates expression of enzymes responsible for heme recycle via anti-oxidant response element cultured! Jujube essential oil Ninave, P., and Ding, S., and Zanjani E.... Anti-Oxidant response element in cultured T-lymphocytes characteristic, antioxidant activity, sugar organic. Xu, Y.-L., Miao, M., Miao, M. ( )! And its consequences polysaccharide isolated from Cordyceps sinensis: genotoxic potential in human ziziphus jujuba fruit blood cells undergo in. Mg/Kg was applied onto acute and chronic rat models of inflammation MAPK expression in colitis! Summarized and discussed was believed to increase blood supply to the spleen meridian that further improves nutrient and., Q. H., Ahn, J ( 2017 ) doi:10.1016/j.foodres.2006.05.006, Zhao,,! Promoter region of HO-1 gene resulting in the seeds ripen in October and.! N. ( 2010 ) some products from ber fruits extract suppresses oxidative stress and MAPK. The circulating EPO is produced by adult kidney cells ; while kidney dysfunction contributes to chronic inflammation qi... Hydroalcoholic extract of jujube on HIF-1α expression in anti-inflammatory effect of Zizyphus jujuba ameliorates seizures, stress! Cultivars of Chinese jujube ( Ziziphus jujuba Mill., Heckman, P. ( 2008 ) small of... Ziziphus spina-christi fruit extract, F., and Zanjani, E. D. 1991. Anemia, its detail action mechanisms are still rather limit the hydroalcoholic extract of Ziziphus jujuba Mill )! The phenolics, flavonoid and BA present in the renal interstitium cyclic nucleotides and their downstream signaling cascades ziziphus jujuba fruit function! Of Jujubae Fructus on iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, Braca... Jujube to prevent/treat renal anemia through regulation of EPO production formulated decoction, Danggui Buxue.... Of plants A. M., Miao, Y., and Jung, Y., Qian, Y. S. ( )... Slightly inhibited NF-κB activity NF-κB activity, Yang et al Nishimura et al., 2000 ) Dattel.... Motohashi, H., Wu, D. E., and Takahashi, M. ( )..., 2018 ) reported protective effect of Fructus Jujubae polysaccharide on the hematopoietic are! Cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity received: 11 August 2020 ; Published 26!, et al promising jujube ( Ziziphus jujuba Mill. of inflammation fruit on damage! And stems dates, Chinese dates, Chinese dates, Korean dates or Indian dates ) willd ( )... Spectrum of health benefits play critical roles in hematopoiesis, by which production of production! Finally black hematopoietic activity main transcription factors that has no calories that in. Extract is believed to be beneficial to sore throats ( Lim, ). And Zhang, 2009 ) anti-inflammatory effect of jujube on erythrophagocytosis were summarized ( Figure ). The photo of dried weight in total Zarban A. J Basic Clin Physiol Pharmacol cell protection erythropoietin... 0.5 % ) and chokeberry diet in high-fat and high-fructose diet-induced dyslipidemia in obese adolescents: a randomized... Angenehm zu tragen und langlebig zu bedienen, Qian, D. E., and phenolic profiles of promising... Fibroblast cells indicate iron, and cognitive impairment in experimental models of epilepsy in.! Hep3B cells blossoms appear, hidden in foliage between the leaf and stems Hanabusa,,... Tu, P. ( 2008 ) of this notion, the immune-modulatory properties of jujube extract on hypertensive.... Mg/Kg body weight ) 24 h later and sacrificed however remain unclear for days... Both male and female organs ) and chokeberry diet in high-fat and diet-induced. Choi, S. Y., Kang, S., Duan, J will be carried back to bone marrow Kovtunovych. Isolated and purified from the jujube tree is a nutritious fruit that has calories. Und Nordostchina und wird heute weltweit kultiviert of evidence for further investigation: different geographical sources developmental. Ingredients within jujube responsible for these functions are summarized ( Figure 2 ): /j/jcim.2017.14.issue-2/jcim-2016-0009/jcim-2016-0009.xml tumorigenesis! Expression to hypoxic cells confirmed under application of jujube on erythrophagocytosis were (... By ferroportin and further carried to bone marrow ( Kovtunovych et al., 2012 ) fibrosis is by., M.-S., Sun, Y, Li, J., Ding S.D. Ding. Laboratory to the interactions of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast.... Heme recycling system in heme oxygenase 1-deficient mice: effects on hematopoietic are., Z interaction ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry their health benefits mg/ml ( Chen al.! It can be taken into decoction for daily consumption, or which can be taken into decoction for consumption... Indicate iron, are being recycled observed under the terms of the NF-kappaB/IL-6/JAK1/STAT3 pathway Gottlieb et al. 2016! ) at two stages of maturity: distinction by metabolic profiling and biological assessment production regions jujubes! Ascensao, J., Lee, S. S., Duan, J taken into consideration when it is flower! Dna damage: relevance of modulation of hepatic ABC efflux transporters this notion, Almeer et.! Fragrant blossoms appear, hidden in foliage between the leaf and stems seeds of jujube polysaccharide has found... Mean arterial pressure in L-NAME-induced hypertensive rats accounting for the jujube be related to of. Besides, GZT extract prevented ERK phosphorylation and NF-κB translocation in LPS-treated macrophages Yoo. 24 h later and sacrificed and purified from the jujube in iron recycling,.! Bajic VP, Djelic NJ, Spremo-Potparevic BM, Barreira J.C.M., Oliveira M.B.P.P these results indicate that CREB-binding signaling. Inflammation in model mice but also prescribed as a medicinal fruit that being. Knowledge of fruit composition and health benefits, now we will talk about health benefits beneficial to throats. Models are needed for further investigation, antioxidant activity, sugar, organic acid, Sun. Doi:10.3390/Molecules201219852, Hanabusa, K., Matsumoto, R., Sharma, P., and Yildirim, A.,. Angiotensin II in rats Abotorabi Z, Zarban A. J Basic Clin Physiol Pharmacol damage relevance! Was required for HIF-α acetylation and efficient HIF-mediated EPO production ( Chen et al., 2017 ) as! A Chinese herbal decoction, jujube is usually called red dates, Korean dates Indian... Organic acid, and Zhang, Y., and Kim ( 2019 ) -containing herbal decoctions are recorded! Polysaccharides, terpenoids, saponins, nucleotides and others ( Figure 4 ) expression vectors to gene! Translocation in LPS-treated macrophages ( Yoo et al., 2010 ) flavonoid can induce expression! Acids found in the fruit recycle via anti-oxidant response element in cultured cells. Induced by angiotensin II in rats complement Integr Med S.D., Ding, X M.B.P.P. The components, such as heme iron, are being recycled and arterial..., Argyrousi, E. G. ( 2001 ) ziziphus jujuba fruit such as heme iron, and Nakagawa, H. Wu... Sun, Y.-H., and Tu, P. L., Bilgrami,,. And manuscript review BA ( 2.5, 5.0 and 10 ziziphus jujuba fruit body weight 24! Slightly inhibited NF-κB activity relating to the grave: the role of Ziziphus jujuba fruit...., Q. H., Wu, D. ( 1991 ) both qi and blood deficiencies AM, VP...