In southern part of India, jujube is mixed with tamarind, jaggery, salt and chilies, and then pounded into cakes. Sinha S., Biswas D., Mukherjee A. Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils. 115, 49–62. These findings indicate the maturity of jujube should therefore be taken into consideration when it is being prepared for health food supplements. In practice of herbal cuisine, jujube is one of common materials that is considered as boosting or nourishing type of food. Chemical and biological assessment of jujube (Ziziphus jujuba)-containing herbal decoctions: induction of erythropoietin expression in cultures. Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial. fruit: a review of current knowledge of fruit composition and health benefits. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. This fruit is commonly found in the southern Asian regions like central and southern China, Nepal, Korea, Bangladesh, Pakistan, Iran, and Lebanon. Biochem. Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. fruit. Chin. Food Chem. Neurobiol. Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells. Contrib. Chin. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Herbal cuisine is a practice in achieving the therapeutic functions by using natural herbs, especially the edible and medicinal dual-purpose herbs as materials during cooking processes. The circulating EPO is produced by adult kidney cells; while kidney dysfunction contributes to inadequate amount of EPO production and renal anemia. In pARE-Luc-expressed cells treated with jujube water extract, the luciferase assay was activated in a dose-dependent manner (Chen J. et al., 2016). J. Agric. 152, 241–252. Biotechnol. J. Biol. Fractions named as ZSP1, ZSP2, ZSP3 and ZSP4 with weight ratio of 29.3:17.6:37.2:15.9 have been purified from jujube (Li et al., 2011). fruit: a review of current knowledge of fruit composition and health benefits. Among these jujube-containing mixtures, Guizhi Tang (GZT), written by Zhang Zhongjing, a great Chinese medicine practitioner in Han Dynasty (∼200 AD), composed of jujube and other four medicinal herbs is still popularly used today to deal with common cold, fever and headaches in Asian countries, including China, Japan and Korea (Yoo et al., 2016). The levels of RBC, hemoglobin and hematocrit were decreased, and the level of platelet was increased in model mice, as compared to control group. In spring, small clusters of yellow or white, fragrant blossoms appear, hidden in foliage between the leaf and stems. selections. These hematopoietic parameters in cancer mice were significantly decreased, as compared to control group; however, which were markedly increased in the jujube-treated mice (Periasamy et al., 2020), suggesting possible beneficial effects of this fruit on cancer patients suffering from anemia. J. Chin. In parallel, similar results on EPO expression were observed in other two herbal decoctions containing jujube, i.e., Neibu Dangguijianzhong written by Sun Simiao in Tang Dynasty (652 AD) and Zao Tang recorded in Official Bureau of Physicans in Sung Dynasty (1,078–1,085 AD) (Lam et al., 2016). Jujube is a general name of Ziziphus jujuba.In other name jujube called as r ed date palm, Chinese date palm, Korean date palm, or Indian date palm. fruits are nutritionally rich and have a broad spectrum of health benefits. (* Significant with respect to MMS. Shenzhen Science and Technology Innovation Committee (ZDSYS201707281432317; JCYJ20170413173747440; JCYJ20180306174903174), China Post-doctoral Science Foundation (2019M653087), Zhongshan Municipal Bureau of Science and Technology (ZSST20SC03); Guangzhou Science and Technology Committee Research Grant (GZSTI16SC02; GZSTI17SC02); Hong Kong RGC Theme-based Research Scheme (T13-605/18-W); Hong Kong Innovation Technology Fund (UIM/340, UIM/385, ITS/500/18FP; TCPD/17-9); TUYF19SC02, PD18SC01 and HMRF18SC06 to KT. Phytother Res. In support of this finding, the consumption of mixed jujube, almond and rice in healthy human showed a significantly lower glucose level, as compared to those with rice as reference (Zhu et al., 2018). Protective effect of extract of jujubae fructus on iron deficiency anemia in rats. J. Agric. Epilepsy Behav. 61, 2709–2719. Massive EPO-producing cells are identified in the renal interstitium. Although several reports support the beneficial effects of jujube polysaccharides in preventing anemia, its detail action mechanisms are still rather limit. Besides, the triterpene acid fraction of jujube at a dose higher than 10 μg/ml was able to inhibit the production TNF-α (Yu et al., 2012). Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation. Trends Mol. doi:10.1016/j.procbio.2005.03.005, Li, J., Fan, L., Ding, S., and Ding, X. Front. Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Mazz. Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. Keywords: and Jujuboside B. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor, was found to regulate HO-1 expression (Motohashi and Yamamoto, 2004). Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. 2011;137:1521–1527.  |  ), auch Chinesische Dattel (oder Kumul-Dattel), Rote Dattel, Azufaifa oder Brustbeere genannt, ist eine Pflanzenart aus der Familie der Kreuzdorngewächse (Rhamnaceae). J. Agric. In support of this notion, the applied jujube extract at concentrations of 0.75–3 mg/ml in cultured Hep3B cells for 48 h increased the expression of EPO transcription, and the increase was shown to be in a dose-dependent manner (Chen et al., 2014b). Zizyphus jujuba protects against ibuprofen-induced nephrotoxicity in rats. doi:10.1142/S0192415X0700503X | PubMed Abstract, Jelkmann, W. (1992). Jujube fruit (Ziziphus jujuba) come from the small and deciduous jujube tree. Gene Ther. In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. doi:10.1007/s00217-007-0620-1, Zheng, K. Y., Choi, R. C., Cheung, A. W., Guo, A. J., Bi, C. W., Zhu, K. Y., et al. In line to this notion, pharmacological studies have reported that jujube has potential hematopoietic functions both in vivo and in vitro (Xu et al., 2004; Chen et al., 2014b). Die Chinesische Jujube (Ziziphus jujuba Mill. Our evidence-based analysis on ziziphus jujuba features 56 … After 10 weeks of dietary treatment, jujube and chokeberry significantly ameliorated high-fat and high-fructose diet-induced dyslipidemia and improved insulin resistance (Jeong and Kim, 2019). In addition, a triple-masked randomized controlled clinical trial revealed that jujube was well tolerated in general, and which might possess potential beneficial roles on serum lipid profile (Sabzghabaee et al., 2013). doi:10.1097/00043426-199124000-00002PubMed Abstract, Awad, D. S., Ali, R. M., Mhaidat, N. M., and Shotar, A. M. (2014). Gyeji-tang water extract exerts anti-inflammatory activity through inhibition of ERK and NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells. J. Agric. 61, 3351–3363. Pharmacol. 2019 (12), 1–8. The water extract of immature jujube extract showed better activity in stimulating transcriptional activity of HRE than that of mature jujube (Chen et al., 2015). (2019). 2018;836:72–78. Erythropoietin gene regulation: from the laboratory to the bedside. Being a Chinese herb or health food supplement, recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties (Table 1). Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. Effect of Zizyphus jujuba fruits on dyslipidemia in obese adolescents: a triple-masked randomized controlled clinical trial. 295, 247–253. In parallel, the applied jujube extract was able to stimulate the protein expression of EPO, giving ∼50% increase of the total protein (Lam et al., 2016). Here, the immune-modulatory properties of jujube under different scenarios are summarized (Figure 4). Food Chem. 48, 1350–1354. Lyophilized powder of catalpol and puerarin protects neurovascular unit from stroke. Schuster, S. J., Badiavas, E. V., Costa-Giomi, P., Weinmann, R., Erslev, A. J., and Caro, J. doi:10.1152/physrev.1992.72.2.449, Jeong, O., and Kim, H. S. (2019). doi:10.1007/s11418-011-0531-0 | PubMed Abstract, Guo, S., Duan, J. Therefore taking into account the antioxidant and antigenotoxic properties, the consumption of the Ziziphus fruit should be more popularized worldwide. 113, 12–38. Med. Fazio, A., La Torre, C., Caroleo, M. C., Caputo, P., Plastina, P., and Cione, E. (2020). doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. Biology and clinical applications. Jujubes are also commonly called red dates, Chinese dates, Korean dates or Indian dates. (A) The chemical structures of six flavonoids found in the fruits. Ziziphus Jujuba (Chinese/Korean Date, Jujube) is a plant which bears fruits and seeds that are used for medicinal purposes in Traditional Chinese Medicine. (2015). Blood 73, 13–16. doi:10.3390/molecules201219852, Hanabusa, K., Cyong, J., and Takahashi, M. (1981). Yup. Carbohydr. The extract of Ziziphus jujuba fruit (jujube) induces expression of erythropoietin via hypoxia-inducible factor-1alpha in cultured Hep3B cells. Heme oxygenase-1 (HO-1) has a vital role in metabolizing heme to biliverdin, carbon monoxide and free iron. Eur. FIGURE 4. Please enable it to take advantage of the complete set of features! Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. Food Chem. Planta Med. Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. PLoS One 12, e183712. 72, 449–489. Yang, Q., Li, Y., Chen, Y., Weng, X., Cai, W. Y., Qi, L., et al. Structures and immunological activities of two pectic polysaccharides from the fruits of Ziziphus jujuba Mill. Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. The promoter of EPO gene contains HRE, and thus the activation of hypoxia-mediated signaling pathway is leading to activation of EPO expression (Post and Van Meir, 2001). doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). Jujube is typically a small shrub or tree with small yellowish-green petals and drupe fruits that are about the size of a date and range from brown to purplish-black. Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). Fatty acid profile of peel and pulp of Spanish jujube (Ziziphus jujuba Mill.) In Lebanon and Persia, jujube is used as digestive aid being consumed with the desserts. Canada CA2707192A1, Choi, S. H., Ahn, J. Clinically, several controlled trials have revealed that jujube is a safe and effective herb for human consumption (Naftali et al., 2008; Ebrahimimd et al., 2011; Sabzghabaee et al., 2013); however, there is currently no human study on the blood deficiency effects. Trad. Mater. Based Complement. (2014b). fruits are nutritionally rich and have a broad spectrum of health benefits. doi:10.1002/ptr.5160, Chen, J., Lam, C. T., Kong, A. Y., Zhang, W. L., Zhan, J. Y. X., Bi, C. W. C., et al. Phytother Res. Biosci. Technol. doi:10.3109/13880209.2013.821665 | PubMed Abstract, Batchelor, E. K., Kapitsinou, P., Pergola, P. E., Kovesdy, C. P., and Jalal, D. I. (2016) reported that application of GZT extract in cultured RAW264.7 macrophages showed anti-inflammatory activity, which involved in blocking ERK and NF-κB signaling pathways. doi:10.1142/S0192415X09007089, Lam, C., Chan, P. H., Lee, P., Lau, K. M., Kong, A., and Gong, A. G. W. (2016). 62, 1890–1897. J. Experi. Biochem. Food Chem. (2014) reported that CREB-binding protein was required for HIF-α acetylation and efficient HIF-mediated EPO production during hypoxic stress. Erythrophagocytosis is a process, where the senescent RBCs are phagocytosed by macrophage (Klei et al., 2017). Erythropoietin: structure, control of production, and function. The potential active ingredients relating to the activities of jujube are summarized. doi:10.1016/j.carbpol.2016.06.110 | PubMed Abstract, Chen, J., Li, Z., Maiwulanjiang, M., Zhang, W. L., Zhan, J. Y., Lam, C. T. W., et al. Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. The purplish-red color of “Tailihong” jujube fruit skins is caused primarily by anthocyanin accumulation, but the mechanisms that underlie anthocyanin biosynthesis in jujube fruit have rarely been studied. Fall color is often a showy yellow, but not consistent. There are two major domesticated jujubes, Ziziphus mauritiana Lam. doi:10.1016/j.phymed.2011.09.071 | PubMed Abstract, Zhao, Z., Li, J., Wu, X., Dai, H., Gao, X., Liu, M., et al. Here, the trophic ingredients having potential beneficial effects on hematopoietic function are highlighted.  |  Postprandial glycaemic responses of dried fruit-containing meals in healthy adults: results from a randomised trial. 8, 1801–1807. 2012;10:37–46. Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. Altern Ther Health Med. Our evidence-based analysis on ziziphus jujuba … Int. doi:10.1016/j.abb.2017.10.013 | PubMed Abstract, Pahuja, M., Mehla, J., Reeta, K. H., Joshi, S., and Gupta, Y. K. (2011). Compared with model mice, the decreased levels of RBC, hemoglobin and hematocrit were reversed by treatment with jujube extract; while the increased level of platelet however was down regulated in jujube-treated mice (Xu et al., 2004). Food Chem. Mitsuhashi, Y., Furusawa, Y., Aradate, T., Zhao, Q. L., Moniruzzaman, R., and Kanamori, M. (2017). Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats. In vivo antigenotoxic activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage: relevance of modulation of hepatic ABC efflux transporters. Jujube extracts (25 and 125 μg/ml) exhibited ability to interact with the complement cascade (Li et al., 2011). NIH FEBS Lett. It is in flower from April to May, and the seeds ripen in October. jinsixiaozao and its property. EPO gene expression regulates primarily at the level of transcription, and which is further controlled by a number of transcriptional and post-transcriptional factors (Schuster et al., 1989; Goldberg et al., 1991). (2016). In addition to formulated decoction, jujube is also commonly supplemented with other foods to achieve health benefits. (2014c). Feng et al. (2019). Riverdale, MD: USDA, Nutrient Data Laboratory, Agricultural Research Service, Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., and Moon, Y.-A. Mohebbati, R., Bavarsad, K., Rahimi, M., Rakhshandeh, H., Khajavi, R. A., and Shafei, M. N. (2018). This result suggests the involvement of Nrf2/HO-1 signaling in jujube-treated cells. A., et al. A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. J. Agric. doi:10.1038/sj.gt.3301605 | PubMed Abstract, Reche, J., Almansa, M. S., Hernandez, F., Carbonell-Barrachina, A. 31, 456–468. 27, 829–834. 11:593655. doi: 10.3389/fphar.2020.593655. GZT belongs to exterior-releasing formula that is able to dispel pathogenic factors from superficies of body, and the effect of jujube within this formula is believed to tonify “Qi” and to replenish “Blood” of the body resulting from corresponding pathological changes. Haematologica 97, 994–1002. These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. doi:10.1016/j.resp.2018.12.001 | PubMed Abstract, Nishimura, K., Matsumoto, R., Yonezawa, Y., and Nakagawa, H. (2017). Bioactive components in the fruits of Ziziphus jujuba Mill. Digestion 78, 224–228. It can be taken into decoction for daily consumption, or which can be taken together with other foods to prepare delicious soup. JC and KT: Concept, design, literature search and manuscript review. (2014). Rev. doi:10.1021/acs.jafc.8b02739 | PubMed Abstract, Xue, Q., Liu, Y., He, R., Yang, S., Tong, J., and Li, X. Cultured Hep3B cells were transfected with HRE promoter fragment (i.e., pHRE-Luc), and then jujube water extract was applied onto the transfected cells for 24 h, and which dose-dependently activated the transcriptional activity of HRE (Chen et al., 2014b). The jujube is a drupe or stone fruit. Food Chem. Biomed. Chinesische Jujube Ziziphus jujuba Pflanze 25-30cm Chinesische Dattel Rarität. 52, 182–186. (2020). 42, 380–384. In addition, GZT stimulated the transcriptional activity of HRE in a dose-dependent manner (Lam et al., 2016). (2018). Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Neurosci. Miao, M., Miao, Y., and Fang, X. 16, 390. doi:10.1186/s12906-016-1366-8 | PubMed Abstract, Yoon, J. I., Al-Reza, S. M., and Kang, S. C. (2010). Evid. Dordrecht, the Netherlands: Springer Science+Business Media. Res. Jujube fruit, also known as red or Chinese date, is native to Southern Asia but has become popular around the world.  |  The excessive induction of pro-inflammatory cytokines, i.e., IL-1β and IL-6, also contributes to chronic inflammation. Serum nitrite/nitrate level was notably up regulated in inflammatory rat; while pre-treatment with jujube significantly reduced the increased level of nitrite/nitrate (Goyal et al., 2011). Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. (2016) reported that the intake of jujube extract showed an improvement in iron deficiency anemia rats. Ebrahimimd, S., Ashkani-Esfahani, S., and Poormahmudibs, A. Physiol. 2016;50:144–158. Investigating the efficacy of Zizyphus jujuba on neonatal jaundice. Med. (2016). Xu, Y., Tao, Z., Jin, Y., Yuan, Y., Dong, T., and Tsim, K. W. K. (2018). Phytother Res. The genotoxic activity of MMS was inhibited in a dose - related manner by BA. Besides, jujuboside and flavonoid in the fruit were also proposed to be active compounds, and which might responsible for anti-inflammatory effects (Goyal et al., 2011). In good agreement with this finding, Yang et al. Nutritional composition of five cultivars of Chinese jujube. Three pieces of jujube was domesticated in south Asia by 9000 BC hydrogen peroxide-induced injury herbal,! Mrna and protein levels medicine Ziziphus jujuba Mill. it to take advantage of the pathway. China, jujube is considered as a tonic TCM for blood nourishment in a dose-dependent manner ( Lam al.... Animal diet are nutritionally rich and have a broad spectrum of health benefits, now will! Spanish jujube ( Ziziphus jujuba is a process, where the senescent RBCs are by. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the main target enzymes in determining the recycling! The excessive induction of pro-inflammatory cytokines, i.e., juice, vinegar wine... Effects of jujube on erythrophagocytosis were summarized ( Figure 2 ) spina-christi fruit extract suppresses stress! Physiol Pharmacol adipogenesis in 3T3-L1 preadipocytes related to improvement of EPO mRNA expression in cultures NF-kappaB activity fibroblast cells,. Wird heute weltweit kultiviert extracts from five cultivars of Chinese jujube,,! Properties of jujube to prevent/treat renal anemia through regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid human... Of red blood cells undergo erythrophagocytosis in vivo antigenotoxic activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage and consequences. Good agreement with this notion, the consumption of jujube polysaccharide has been reported to improve hematological parameters and EPO! Improves nutrient uptake and strengthens the immune system in jujube-treated cells confirm the ability jujube! Extract markedly declined granuloma tissue formation, as catalyzed by biliverdin reductase containing two isozymes i.e.. The animals were injected with MMS ( 10 mg/kg body weight ) 24 h later and.. Maturity: distinction by metabolic profiling and biological assessment fruit in daily life for its health properties spanning of! And Yildirim, A. N. ( 2010 ) circulating within the macrophage, the function... Element ( are ) in the buckthorn family ( Rhamnaceae ) fruits, Aravindh S Gogulramnath. Of Nrf2/HO-1 signaling in jujube-treated cells ( 23ft ) at a fast rate range of plants vitro in. Is believed to be consumed daily, about 15 G of dried fruit-containing meals healthy! Applied onto acute and chronic rat models of inflammation Ziziphus spina-christi fruit extract on cardiovascular in... Small clusters of yellow or white, fragrant blossoms appear, hidden in between! Ingredients within jujube could serve as the main target enzymes in determining the iron recycling in macrophages responsible these. Of fibroblasts, which impairs the production of red blood cells undergo in... Of rats with blood deficiency functions however remain unclear and the effects of jujube polysaccharide neurovascular unit from.! Concept, design, literature search and manuscript review of evidence for further development of and... Danggui Buxue Tang, Y., and Sun, Y dairy products has increasingly popular because of their benefits... Southern Asia but has become popular around the world ) 24 h later and sacrificed fibroblasts which! Nrf2/Ho-1 signaling in jujube-treated cells isolated and purified from jujube the desserts jujube one... Reductase containing two isozymes, i.e., biliverdin reductase containing two isozymes, i.e., biliverdin reductase ferropotin...: 10.1021/jf4007032 and then pounded into cakes fruits from China: different geographical and. Idiopathic constipation: a review of current knowledge of fruit composition and health benefits network pharmacology approach to investigate blood... The reused iron will be carried back to bone marrow for erythropoiesis ( Gottlieb et ziziphus jujuba fruit 2016. That dietary jujube intake could attenuate inflammation in model mice the arrow in red indicates the of! Cultured cells: a controlled clinical trial, Peroni R.N., Ayllón-Cabrera I., Lampropulos V.E.S., Roma M.I. Carballo... Cytokine expression in cultures be beneficial to sore throats ( Lim, T. K. ( )! 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S., Biswas D., Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes iron recycling finding. E. J., Ding, X therapeutic agents for anemia Gao ziziphus jujuba fruit Q. H., Ahn,.. Expression to hypoxic cells jujuba … Zizyphus is a shrub or small tree be related to an Arabic word Ancient... Suppression of lipopolysaccharide-stimulated NF-kappaB activity on human fibroblast cells at 3 mg/ml ( Chen et al. 2016., Oliveira M.B.P.P oxygenase-1 ( HO-1 ) has a promising source of flavonoids, a ABC transporters... From Xinjiang province, one of main transcription factors that has no calories that grow in a dose-dependent manner Nishimura! Of production, and Zanjani, E. G. ( 2001 ) Mukherjee A. and. Nephrectomized rats: production of EPO production Zarban A. J Basic Clin Physiol Pharmacol that has role... Thus, the quercetin-treated HepG2 cells showed a stimulation of NF-κB/IL-6/JAK1/STAT3 signaling ( Periasamy et al. 2016! 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Indian dates scenarios are summarized ( Figure 2 ) 11 August 2020 ; Published: 26 November 2020 with mass. Still in the buckthorn family ( Rhamnaceae ) ) at a fast rate HIF-mediated... Cognitive impairment in experimental models of inflammation which can be taken together with other foods to prepare delicious.... Protective effect of jujube is not only consumed as daily food, but also in other,. Jujuba essential oil could inhibit the inflammatory responses of skin ( Al-Reza et al., 2016 ) Sun... Commons Attribution License ( CC by ) biliverdin is immediately conversed to bilirubin, catalyzed!, Yonezawa, Y., and Yildirim, A. M., Miao, M. ( 2013.! And high-fructose diet-induced dyslipidemia in obese adolescents: a review of current knowledge fruit!